Monday, January 29, 2018

Bulbs With Benefits : The Surprising Effects of Garlic by Jerry Brainum

In this era of high-tech super supplements, it's easy to overlook some of the good old standbys. One such is supplement is garlic or even eating garlic itself. Garlic is not found in the typical bodybuilding nutrition regimen. If more bodybuilders knew about the good things that garlic does, though, they might consider adding a garlic supplement.

Garlic's benefits come from its sulfur content, which is also is true to an extent of onions. The sulfur compounds in garlic have been showing clinical studies to lower elevated blood lipids, such as cholesterol, provide antioxidant activity and lower elevated blood glucose, which may help prevent diabetes. In addition, garlic has shown anticancer activity in a number of studies, most famously lowering blood pressure. In fact a new study turned up that effect.

How garlic brings down blood pressure is of interest to bodybuilders. Just a few years ago nitric oxide was an obscure substance known only to medical researchers. It gained prominence in the bodybuilding community with the advent of supplements touted to boost its presence in the body. The reasoning: Since one of the primary effects of NO is that it dilates  blood vessels, the enhanced blood flow that results will increase the delivery of oxygen and nutrients to working muscle, which will have an ergogenic effect. In addition, NO is involved in the release of anabolic hormones, including testosterone and growth hormone.

Typical NO bodybuilding supplements contain the amino acid L-arginine as their primary ingredient. Arginine is the immediate precursor of NO synthesis in the body. Still, what determines how much NO is produced isn't arginine but rather the activity of enzymes that convert arginine into NO.

It turns out that garlic also boosts NO in the body. That's likely the reason that garlic lowers blood pressure, since the increased NO that results from eating garlic will dilate blood vessels. In addition, NO is rapidly degraded because of oxidants, and garlic's antioxidant activity should help extend NO activity.

Garlic is also great for your brain. Studies show that garlic helps protect the brain through its antioxidant activity. That's significant because the brain is loaded with polyunsaturated fat, such as the omega-3 fatty acid DHA. Such fats are highly prone to oxidation, however, and that opens the door to brain degeneration. Oxidation often produces excess inflammation, which is associated with Alzheimer's disease and other brain ills. 

Animal-based studies show that garlic intake appears to help prevent various brain maladies. Research done with rats given garlic shows increased memory retention.1 The mechanism is increased delivery of the amino acid L-tryptophan to the brain. Tryptophan is the precursor of the brain neurotransmitter serotonin, which helps memory and learning. Garlic helps shunt more tryptophan into the brain for conversion into serotonin.

                                                 In ancient Egypt garlic 

                                                 was distributed to the 

                                                 laborers on the pyramids 

                                                 because it decreased

                                                fatigue and aided recovery.


From an exercise standpoint, garlic offers several benefits.For one thing, it may reduce fatigue. In ancient Egypt garlic was freely distributed to the laborers who built the pyramids because it decreased fatigue and aided rapid recovery. For the same reasons it was given as a tonic to soldiers and athletes in ancient Rome. Other studies link garlic to increased muscle strength. No doubt the enhanced blood circulation that it brings plays a role. Mice and other lab animals supplemented with garlic show increased running times to exhaustion on treadmills, as well as longer swimming times.

Human studies with garlic show that it reduces the workload on the heart during exercise and reduces peak heart rate, which points to less heart stress during vigorous exercise. By helping lower high counts of cytokines, immune proteins that increase during exercise, garlic helps lower excess inflammation and speed up and improve exercise recovery.

A more recent study showed that an active ingredient in garlic may even help prevent excess muscle breakdown.2 The research involved isolated-muscle-cell exposure to garlic, specifically an ingredient in aged garlic called daillyl sulfide, or DAS. The cells were exposed to high heat, which results in cell breakdown, but when DAS was added to the muscle cell culture, the breakdown was blocked.

In another part of the study, rats with implanted tumors, who experience cachexia, or the accelerated loss of muscle that occurs in 80 percent of human cancer patients, were given DAS. So was a group of normal rats. While the cancer stricken rats didn't show any effects from the garlic compound, the normal rats had significant increases in muscle. Again, the mechanism was thought to be a blunting of the normal catabolic effects in muscle, which would tip the metabolic scales toward anabolism, or growth. Anabolic steroid drugs produce larger muscles because they provide both anabolic and anticatabolic effects.

While garlic cannot be characterized as a "super muscle growth" supplement, the fact that it helps prevent excess muscle breakdown in normal animals suggests that it may encourage similar effects in bodybuilders when used in conjunction with other anticatabolic supplements, such as whey and casein proteins, HMB and fish oil.


1 Haider,S.,et al.(2008). Repeated administration of fresh garlic increases memory retention in rats.J Med Food 11:675-79

2 Olivan,M.,et al.(2010) Nutraceutical inhibition of muscle proteolysis: A role of diallyl sulphide in the treatment of muscle wasting. Clin Nutr. In press




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The Applied Ergogenics blog is a collection of articles written and published by Jerry Brainum over the past 20 years. These articles have appeared in Muscle and Fitness, Ironman, and other magazines. Many of the posts on the blog are original articles, having appeared here for the first time. For Jerry’s most recent articles, which are far more in depth than anything that appears on this blog site, please subscribe to his Applied Metabolics Newsletter, at This newsletter, which is more correctly referred to as a monthly e-book, since its average length is 35 to 40 pages, contains the latest findings about nutrition, exercise science, fat-loss, anti-aging, ergogenic aids, food supplements, and other topics. For 33 cents a day you get the benefit of Jerry’s 53 years of writing and intense study of all matters pertaining to fitness,health, bodybuilding, and disease prevention.


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